KEGG pathway enrichment analysis forecasts the complicated pathways for a general understanding of changes on B cells after infection This study showed that the top enriched KEGG pathways were “ECM-receptor interaction,” “hematopoietic cell lineage,” “PI3K-AKT signaling pathway,” and “JAK-STAT signaling pathway.” PI3K-AKT signaling pathway is engaged in regulating multiple cellular functions such as transcription, translation, proliferation, growth, and survival (44). The gene discussed is PIK3CD; the disease is infection.