MTOR and pancreatic neuroendocrine tumor: These data are in line with what has been previously reported even in the BON-1 cell line, a model of pancreatic neuroendocrine tumor, in which a long-lasting (8 weeks) exposure to EVE induced mTOR pathway inactivation of pp70S6K on Thr389 and of p4eBP1 on Thr70 (23).