The prediction model showed (Figure 1) that seven TGF-β family members (BMP2, BMP6, GDF6, GDF7, GDF10, LEFTY2, and TGF-β1) could be potential independent prognostic factors for HCC, which was validated by Kaplan–Meier survival analysis and ROC analysis (Figure 2), and further by LASSO analysis and PCA analysis (Figure 2). This evidence concerns the gene LEFTY2 and hepatocellular carcinoma.