Similarly,semaphorin 4G (SEMA4G, which has been suggested as tumor suppressor gene forcolorectal cancer [33]) is downregulatedwith PROL1 overexpression (Log2FC = –4.8,p-value, 9 × 10−18) and isupregulated with PROL1 knockout (Log2FC = 2.6,p-value, 1.2 × 10−13). Here, OPRPN is linked to cancer.