As a result, 3 DEmRNAs from CCI with memory impairment model rats (ATF3, C1QC, and CD68) and 13 DEmRNAs from SNI and CCI models (ADAMTS2, BCL6B, CLCF1, RBP1, and TPBG, among others) overlapped with SNI and CCI models, respectively (Supplementary Figure S3A, Supplementary Table S6). The gene discussed is TPBG; the disease is memory impairment.