11 DEmRNAs (APOC1, TMEM106A, TSC22D4, CYR61, BCL6B, MRVI1, LAMC3, BAIAP3, CTXN3, TPBG, and C4B) and 24 DEmRNAs (ABHD10, ARC, CARTPT, CD3E, CLCF1, KIF14, OXTR, RARRES1, SLC18A1, and SLC2A9, etc.)of CCI with memory impairment model rats overlapped with AD and HD model, respectively. The gene discussed is CD3E; the disease is Alzheimer disease.