ZBTB1 and Immunodeficiency: Zbtb1 plays a key role in T cell development and lymphocyte development, mRNA encoding Zbtb1 is most highly expressed in hematopoietic stem cells, thymocytes and pre-B cells, In addition to its role in T cell development, it was also demonstrated to be involved in the differentiation of B cells and NK cells, homozygous knockout of the Zbtb1 gene leads to severe combined immune deficiency in mice (Punwani et al., 2012; Lu et al., 2017).