TNF and cancer: KEGG enrichment of genes annotated in chromosome differentially open regions and differentially expressed mRNAs (Figures 1O,P) found they were significantly enriched in lymphatic development-related pathways such as Th1 and Th2 cell differentiation, Th17 cell differentiation, etc. The signaling pathways related to cell growth, apoptosis and damage repair, such as MAPK, cancer pathways and TNF, were significantly enriched.