Among these mutated infertility genes, mutations of FSIP2, CFAP69, CEP19, MSH5 or MCM8 are recessive for spermatogenic failure or premature ovarian insufficiency (Guo et al., 2017; Dong et al., 2018; Martinez et al., 2018; Yildiz Bolukbasi et al., 2018; He et al., 2019; Liu et al., 2019; Zhang et al., 2020). The gene discussed is MSH5; the disease is Premature ovarian insufficiency.