NFKB1 and acute respiratory distress syndrome: Most strikingly, we show that the drug-free C11G3-TBP nanomicelles display inherent anti-inflammatory activity to inhibit the expression of NF-κB, and the combination with Cur in a formulation of C11G3-TBP@Cur nanomicelles can fully take advantages of each party to boost combination therapy of ALI through downregulation of NF-κB and pro-inflammatory cytokines and elimination of ROS in the ALI lesion, thereby causing significant inhibition of inflammation infiltration and alveolar wall damage of injured lung tissues.