TNF and acute respiratory distress syndrome: The thus created C11G3-TBP@Cur nanomicelles possess good colloidal stability and cytocompatibility, can effectively scavenge ROS and inhibit the pro-inflammatory cytokine (TNF-α, IL-1β and IL-6) regulation through blocking of NF-κB signal pathway in M1-type alveolar macrophages, and enable effective repolarization of alveolar macrophages to anti-inflammatory M2 type to boost combination anti-inflammatory and antioxidative therapy of LPS-activated alveolar macrophages in vitro and a mouse ALI model in vivo.