SCD and neoplasm: In addition, upon treatment with CAY10566 (25 nM) or sc26196 (500 nM), the number and size of tumor organoids significantly decreased, and the spindle-like morphology was markedly disrupted by >1.89-fold compared with the controls (Figure 3G), suggesting that OvCa cells in EMT status were vulnerable to SCD1/FADS2 inhibition-based therapies.