SPEG and Cognitive impairment: The 4 overlapping DMGs identified in the IF mice subjected to CCH state are Zinc finger (CCCH type), RNA-binding motif and serine/arginine-rich 1 (ZRSR1) that is associated with Parkinson's disease, G Protein Subunit Gamma 10 (GNG10) associated with mild cognitive impairment and AD, ACTG1 associated with AD and SPEG associated with mild cognitive impairment.