First, in vitro fluorescence staining of resected brain tissue slices from APP/PS1 AD and WT mice showed that these three probes could well highlight the Aβ plaques in the cerebral cortex and hippocampus of APP/PS1 mouse (Figure S30, S32 and S34), not in WT mouse (Figure S31, S33 and S35). The gene discussed is APP; the disease is Alzheimer disease.