THBS2 and lung cancer: To investigate whether CAFs are the major source of THBS2 expression and to identify the specific subsets of CAFs, we applied the single-cell RNA sequencing (scRNA-seq) analysis, a powerful tool deconvolving the cell-type composition within tissues and deciphering the transcriptomic profiles of each cell, to two surgical cases with early-stage lung cancer (pT1N0M0) and adjacent normal lung tissues (Figure S7A, B).