THBS2 and neoplasm: The above evidence revealed THBS2 as a secreted protein (Figure S3B) and also a predictive marker for patients' prognosis and treatment response (Figure 2; Figure 3; Figure S3-S5), which was reminiscent of exosomes that are important mediators of cell-to-cell communication and are associated with drug resistance, as well as tumor recurrence/metastasis 14.