THBS2 and cancer: This analysis highlights the rationale for using a single marker THBS2 instead of a combined gene-signature as a predictive biomarker; 5) Previous evidence has revealed THBS2 as a prognostic biomarker (either good or poor) in several cancer types 67-69; 6) However, little is known about its role in promoting the aggressiveness of early-stage LUAD.