In comparison with the standalone vaccine groups (C# and D#), we observed increased frequency of CD4+ and CD8+ central memory T cells (Tcm) in the LNs and spleen from some of the combination groups (E#, F# and G#), which was different in the context of different tumor models, and the underlying mechanistic details might require more investigations (Figure 6G-J, Figure S8-9). The gene discussed is CD8A; the disease is neoplasm.