There are significant tumor necrosis features in E#, F# and G# groups (indicated with yellow arrows), especially when the CD4+ T cells, CD8+ T cells and CD11c+ DCs were in close proximity to each other, suggesting that there might be certain interplay between these T-lymphocytes and antigen presenting cells (APCs) that may consequently contribute to such satisfying tumor suppression vaccine outcomes. The gene discussed is CD4; the disease is neoplasm.