Collectively, the results indicated that the overexpression of Oct4 and c-Myc (and not Sox2 or Klf4) in tumor cells elevates the extracellular levels of Eno1, Hsp90ab1, Eef2, and vinculin and the application of Oct4 CM, c-Myc CM, and Oct4/c-Myc CM to tumor cells and tumor-bearing mice inhibited the growth of tumors (Figure 9H). The gene discussed is MYC; the disease is neoplasm.