The selected protumorigenic genes (Lrp5, MMP9, Runx2, TGFβ, and Snail) were downregulated in Oct4 CM-treated 4T1.2 parental cells, while they were elevated in Oct4-overexpressing tumor cells and reduced in Oct4-silenced tumor cells (Figure S7). The gene discussed is MMP9; the disease is neoplasm.