In our previous studies, iTS cells were also generated from MSCs by overexpressing Lrp5, β-catenin, Snail, or Akt 3, from osteocytes by overexpressing Lrp5 and β-catenin 5, 6, and from tumor cells by overexpressing β-catenin 26. The gene discussed is LRP5; the disease is neoplasm.