ART4 and Anxiety: Increases HSV glycoprotein- specific antibodies which neutralizes HSV-1 and HSV-2Provides remarkable durability of vaccine response (continues up to 21 months post- immunization)Exhibits little to no viral replicationAbsence of viral DNA in brains or trigeminal gangliaProvides protection against nHSV (maternal immunization promotes transfer of neutralizing antibodies and protects offspring from disseminated disease, weight loss, anxiety-like behaviour, and mortality)