Furthermore, in immature Mo-DCs and non-polarized M0 Mo-macrophages differentiated from monocytes isolated after a separate cohort of SLE patients, mostly having an LN flare, PRP6-HO7 again downregulated high-level expression of pro-inflammatory cellular surface molecules such as IFN-I-inducible FcγRI/CD64, a biomarker reflecting ongoing inflammation and nephritis in lupus (53, 54), CD83, CD86, CD80, CD40, and HLA-DR without the need of further stimulation. Here, CD40 is linked to nephritis.