TARDBP and amyotrophic lateral sclerosis: Many proteins are related to ALS, such as superoxide dismutase 1 (SOD1), fusion sarcoma (FUS) and Aaxin-2, among which TAR-DNA-binding protein 43 (TDP-43) is the most relevant; it binds RNA and regulates mRNAs involved in neuronal development (Geuens et al., 2016; Prasad et al., 2019).