The results showed that the AD group, aMCI group, and NC group had no statistically LSD in gender and education level (P > 0.05), but age, MMSE score, MMSE delayed recall sub-score, MoCA score, MoCA delayed recall sub-score, AVLT-H-SR sub-score, AVLT-H-LR sub-score, WMS-VR-IR sub-score, WMS-VR-DR sub-score, BNT, TMT-B, CDT, ADL, HAMA, and plasma Aβ40, Aβ42, and P-Tau were statistically different among the three groups (P < 0.05). The gene discussed is MAPT; the disease is Alzheimer disease.