MAPT and Alzheimer disease: Although the change trend of plasma Aβ and Tau is still controversial, many previous studies confirmed that the change trend of plasma Aβ and Tau could reflect the progress of AD disease to a certain extent (Nakamura et al., 2018; Chatterjee et al., 2019; Chen et al., 2019; Risacher et al., 2019), and similar results were obtained in this study.