Pathological hallmarks of vCJD include the presence of widespread and numerous florid plaques, characterized by a central eosinophilic amyloid core and a pale periphery of radiant fibrils surrounded by a corona of vacuolation, and prion protein (PrP) accumulation as small cluster plaques (Ritchie and Ironside, 2017). The gene discussed is PRNP; the disease is variant Creutzfeldt-Jakob disease.