Inhibition of the Stat3/Snail signaling pathway might be a promising therapeutic strategy to reduce the aggressiveness of HCC cells.20 Brevilin A was found to inhibit the STAT3 signaling in human lung cancer A549 cells.16 In the current study, we found that brevilin A suppressed the phosphorylation of STAT3 and expression of Snail in HCC cells, indicating that brevilin A inactivated the Stat3/Snail signaling pathway. This evidence concerns the gene STAT3 and lung carcinoma.