It is well known that angiogenesis is essential for tumor growth and metastasis; therefore, sesquiterpene lactones may be considered as a promising candidate for preventing the tumor development and progression though inhibiting angiogenesis.14 6-O-Angeloylenolin (6-OA), a sesquiterpene lactone isolated from Centipeda minima, exerts anti-tumor effect against lung cancer.15 You et al.13 reported that brevilin A exhibits anti-tumor activity against colon adenocarcinoma via inducing apoptosis and autophagy of CT26 cells via mitochondrial and PI3K/AKT/mTOR pathways. This evidence concerns the gene AKT1 and lung cancer.