RYR1 and diabetes mellitus: The abnormalities in [Ca2+]i observed in RYR1-p.163C and db/db are consistent with previous reports in malignant hyperthermia susceptible muscle cells (Lopez et al., 1985; Yang et al., 2006; Eltit et al., 2010; Altamirano et al., 2014a) and from experimental models and patients with diabetes (Draznin et al., 1989; Ohara et al., 1991; Tschope et al., 1991).