Figure 5B shows a negative linear relationship between muscle [Ca2+]i and glucose uptake (R = 0.63), and Figure 5C shows a positive linear relationship between muscle [Ca2+]i (average per mouse) and the glucose blood level of RYR1-p.R163C and db/db mice (R = 0.68). In summary, mice with impaired muscle [Ca2+]i handling have significantly reduced glucose uptake and subsequent hyperglycemia. The gene discussed is RYR1; the disease is Hyperglycemia.