Interestingly, though not covered in this review, diminished NHE6 expression has also been detected in astrocytes associated with Alzheimer’s disease, suggesting a broader role for NHE6 is neurodegenerative pathophysiology (Prasad and Rao, 2018a; Prasad and Rao, 2018b). This evidence concerns the gene SLC9A6 and early-onset autosomal dominant Alzheimer disease.