Similarly, NHE5 has been detected in endosomes of C6 glioma cells that partially overlap markers for recycling endosomes where it has been implicated in modulating endosomal pH as well as cell surface delivery and signalling of the hepatocyte growth factor receptor (HGFR; also called the MET receptor tyrosine kinase) and epidermal growth factor receptor (Fan et al., 2016; Kurata et al., 2019). Here, MET is linked to central nervous system cancer.