CHOP is a UPR-induced stressor that intercedes ER-stress-mediated apoptosis,65 and antioxidant treatment in crisimartin induced UPR activation in gall bladder tumours abolished the expression of CHOP induced by crisimartin.66 Thus, collective results depict that UPR induction in the milieu of fatty liver apparently intensifies ER stress in a counter-protective manner and promotes hepatic steatosis with varying substantial contribution of the different UPR branches.67 Here, DDIT3 is linked to fatty liver disease.