The lack of systemic and validated results poses a hindrance in the development of a better treatment strategy for NAFLD, while the current therapy is more directed towards weight loss and increase in insulin sensitivity through exercise and dietary regimes rather than targeting the disease itself.7,8 Over the past few years, medicines from natural sources have earned mounting attention as prospective therapeutic agents to treat NAFLD, accounting for their higher efficacy and lower risk of side effects.9 Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.