F2 and blood coagulation disease: Coagulopathy is characterized by elevated prothrombin time, D-dimer levels, and thrombocytopenia but without hypofibrinogenemia. Al-Ani et al. [23] and Iba et al. [24] suggest that coagulopathy is related to an infection-induced systemic inflammatory response involving endothelial dysfunction and micro thrombosis with organ failure and usually no bleeding.