Although succinylation can be installed non-enzymatically using succinyl-CoA as a cofactor in vitro, it has been revealed that succinylation of H3K79 can be catalyzed by lysine acetyltransferase 2A (KAT2A, also known as GCN5) in cells to promote tumor cell proliferation and tumor development (Wang et al., 2017). This evidence concerns the gene KAT2A and neoplasm.