The current study revealed that CDC42 was positively linked with Th2 cells and their secreted cytokine IL-4 but negatively associated with Th17 cells and its secreted cytokine IL-17A in patients with AIS; however, CDC42 was neither related to Th1 cells nor its secreted cytokine IFN-γ. Here, CDC42 is linked to androgen insensitivity syndrome.