The polymorphism rs1801282 (c.34C>G) in codon 12 of the PPARγ2 gene, which results in the substitution of Proline with Alanine (Pro12Ala), was found to be related to higher insulin sensitivity and diminished risk of T2DM and diabetic nephropathy [39–42] as well as CAD and NAFLD. Here, INS is linked to diabetic kidney disease.