Kumar et al. showed both p.S380N and p.R423H mutations destabilize ALDH3A2 [38], and Kumar et al. also indicated W148R, F161C, and L171R mutations in FLN (filamin) B result in the loss of stability and consequently leading to AOI, LS, and BD phenotypes [27]. This evidence concerns the gene FLNB and Behcet disease.