We can summarize our recent work as follows: (1) we confirmed that the genetic characteristics, namely, the HLA-DRB1 and DQA1 genotypes of the overlap patients, are clearly different from healthy individuals, but not significantly different from genetics of patients with anti-Jo-1 ASSD; (2) myositis-SSc overlap patients have a distinct and unique clinical phenotype, which seems similar in many ways with the phenotype of anti-Jo-1 ASSD patients. This evidence concerns the gene HLA-DQA1 and myositis disease.