PIK3CA and neoplasm: TLR8 (Toll-like receptor 8) initiates juvenile T cells, promotes the secretion of various cytokines by DCs and is involved in the regulation of tumor immune microenvironment (Tran et al., 2019), while FGF2 (fibroblast growth factor 2) is involved in the Wnt/β-catenin, TGF-β and PI3K/Akt pathways to affect the development of LUAD (Dai et al., 2019).