Ogino et al. (2007) had proven that GAPDH mRNA was associated with lung metastasis in osteosarcoma. The poor prognosis of peripheral T-cell lymphoma (Ludvigsen et al., 2018) or hepatocellular carcinoma (Jiang et al., 2017) was associated with triosephosphate isomerase (TPI1). This evidence concerns the gene GAPDH and osteosarcoma.