The expression of ENO1 in the invasion and metastasis of tumor cells was concerned by many studies with high expressions in OS (Chen et al., 2014), breast cancer (Gao et al., 2013), lung cancer (Zhang et al., 2018), and hepatocellular carcinoma (Zhu et al., 2018; Deng et al., 2020). The gene discussed is ENO1; the disease is lung cancer.