Huang et al. could not confirm that GJA1 dysfunction causes heart defects or left–right patterning defects in mice nor did they identify GJA1 disease-causing variants in a cohort of 300 patients with congenital heart disease (Britz-Cunningham et al., 1995; Dasgupta et al., 2001; Huang et al., 2011). The gene discussed is GJA1; the disease is congenital heart disease.