METTL3 and neoplasm: Studies have shown that m6A suppression can promote the proliferation and invasion of gastric cancer cells by activating the Wnt and PI3K-Akt signaling pathways Furthermore, Xia et al found that the m6A-related gene METTL3 was highly expressed in pancreatic tumor cells, and METTL3 knockdown could inhibit the proliferation and migration of tumor cells (Xia et al., 2019).