Although Ang-(1-7) has been shown to elicit protective effects in peripheral tissue in various cardiovascular diseases, it is still unknown whether brain Ang-(1-7) plays an important role in neurohormonal modulation within the PVN in hypertension.25,26 Thus, we aimed to investigate whether brain Ang-(1-7) regulates NO and neurotransmitter levels in the PVN and have a protective effect on cardiac hypertrophy and sympathetic nerve activity in salt-sensitive hypertensive rats. The gene discussed is ANG; the disease is Hypertension.