Nevertheless, the frequent isolation of CF isolates with mutations in the lasR gene (Smith et al., 2006; Hoffman et al., 2009; Folkesson et al., 2012; Feltner et al., 2016; Winstanley et al., 2016), causing inactivation of the las QS system, has been considered a caveat for the development of QS inhibitors in CF therapy (García-Contreras et al., 2013). Here, LIAS is linked to cystic fibrosis.