LIAS and cystic fibrosis: Our findings also suggest that the hierarchically dominant role of the las system over the rhl system, typically reported in PAO1 and PA14 model strains, can be lost in CF isolates, as previously documented in clinical and environmental isolates (Feltner et al., 2016; Chen et al., 2019; Cruz et al., 2020; Groleau et al., 2021).