and negatively correlated with 3-(3-hydroxyphenyl)-propanoic acid and 4-hydroxybenzeneacetic acid; p16Ink4a was negatively correlated with the Prevotellaceae NK3B31 group and positively correlated with Defluviitaleaceae UCG-011; IL-6 was negatively correlated with Atopobiaceae; lung fibrosis degree was positively correlated with Tannerellaceae, Lachnospiraceae, Turicibacter, Parabacteroides, Oscillospiraceae sp. This evidence concerns the gene CDKN2A and pulmonary fibrosis.