Based on cord blood exosomes, this study found that the expression of GDF3, PROM1, AC006064.4, lnc-HPS6-1:1, and circ_0014635 were significantly increased, and the expression of lnc-ZFHX3-7:1 was significantly decreased in cord blood exosomes of patients with GDM-M, which will help to understand the pathogenesis of GDM-related macrosomia. Here, PROM1 is linked to gestational diabetes.