Based on FC ≥ |3.0|, P < 0.001, and relatively high abundance, we then selected 5 mRNAs (NUTM1, GDF3, C17orf105, PROM1, and NFE2L1), 10 lncRNAs (AC073912.1, IL10RB-DT:19, lnc-FAM49B-4:1, lnc-ZFHX3-7:1, AC006064.4, lnc-HPS6-1:1, lnc-SEC11A-2:1, lnc-CAPZA3-3:2, lnc-TNFSF13B-2:1, and lnc-SOX6-1:1), and 10 circRNAs (circ_0012756, circ_0041183, circ_0065086, circ_0014635, circ_0075695, circ_0074153, circ_0068824, circ_0048469, circ_0066837, and circ_0026688) and validated their expression in cord blood exosomes from 20 patients with GDM-M and 20 controls. This evidence concerns the gene PROM1 and gestational diabetes.