SRPX2 and Rolandic epilepsy: The hyaline repeat domain folds similarly to the IG-like domain found in the protein Hig from Drosophila. The Y72S mutation identified in patients with Rolandic epilepsy is in the immediate vicinity of a cysteine residue that is predicted to participate in the disulfide bond of the SRPX2 CCP domain (Roll et al., 2006), showing the importance of CCP domains for the brain function of SRPX2.