EMX2 and glioblastoma: While EMX2 functions in promoting cell differentiation in the developing brain, it is considered as a possible tumor suppressor in different cancers, such as sarcoma, colorectal cancer, gastric tumors, and glioblastoma (Table 3; Li et al., 2012b; Aykut et al., 2017; Jimenez-García et al., 2021a,b).