Moreover, a decrease in both GABAergic and cholinergic interneurons in the ventral telencephalon has been reported in Tourette Syndrome, suggesting LHX6 and LHX8 correlation with Tourette Syndrome due to their role in GABAergic and cholinergic interneuron specification in the striatum (Pagliaroli et al., 2020). Here, LHX8 is linked to Tourette syndrome.