OTX1 and OTX2 are overexpressed in medulloblastoma (Boon et al., 2005; Zakrzewska et al., 2013), which is a malignant pediatric brain tumor located in the posterior fossa that is divided into four molecular groups based on genomic and transcriptomic alterations: Wnt, SHH, Group 3, and Group 4 (Rudin et al., 2009; Northcott et al., 2011; Taylor et al., 2012). This evidence concerns the gene OTX2 and medulloblastoma.