Currently, several PDE5 inhibitors have been approved by the FDA for the treatment of erectile dysfunction (sildenafil, vardenafil, tadalafil, avanafil, udenafil, and mirodenafil) and pulmonary arterial hypertension (PAH) (sildenafil and tadalafil).9 Moreover, extensive studies have revealed that PDE5 inhibitors are potent for the treatment of other diseases, such as lower urinary tract symptoms (LUTS),10 heart failure and coronary artery disease,11 neurological disorders12 and so on. Here, PDE5A is linked to heart failure.