Univariate analyses showed that among the main patient characteristics, CD4 + T lymphopenia, total lymphocyte count, performance status ≥2 and advanced NSCLC were associated with worse OS (Table 3): CD4+ T lymphopenia (HR 1.61 [95% CI = 1.107; 2.358] p = 0.012); performance status ≥2 (HR 2.88 [95% CI = 1.88; 4.405] p < 0.0001); advanced stage (HR 3.03 [95% CI = 2.08; 4.43] p < 0.0001)); total lymphocyte count < 1000/μL (HR 1.65 [IC 95% = 1.06; 2.56] p = 0.0262). This evidence concerns the gene CD4 and lymphopenia.