It was suggested that CHD is closely related to smoking, hypertension, diabetes, alcohol consumption, obesity, HDL-C, FGF23, SAH, Hcy and HOMER1, and FGF23, SAH, Hcy and HOMER1 are new risk factors for CHD, which may have an important reference value for the clinical diagnosis of CHD. The gene discussed is HOMER1; the disease is obesity due to melanocortin 4 receptor deficiency.