Of these, 51 individuals had rare intronic TREs in one or more of the 38 genes that are associated with neurological abnormality, abnormal behavior or nervous system abnormality in Mammalian Phenotype Ontology, including genes previously associated with schizophrenia such as DCLK1, ERBB4, GRIK4, GRIN2A, SHANK1, and VIPR2 (Supplementary Table S3). The gene discussed is SHANK1; the disease is schizophrenia.