Secondary endpoints included: incidence of fever during neutropenia (defined as a tympanic temperature ≥ 38.5 °C and an absolute neutrophil count (ANC) < 0.5 × 109/l, or expected to fall below 0.5 × 109/l in the next 48 h), CRP levels, intestinal mucositis as measured by (the AUC of) citrulline, clinical mucositis as determined by daily mouth and gut scores, incidence and type of BSI, short term overall survival (100 days and 1 year after HSCT), length of hospital stay in days and use of systemic antimicrobial agents, analgesic drugs and total parenteral nutrition (incidence and duration). This evidence concerns the gene CRP and Decreased total neutrophil count.