The LCV significant findings (FDR ≤ 0.05) include genetic causality on migraine for higher levels of two blood proteins, including dickkopf WNT signalling pathway inhibitor 1 (DKK1, GCP = 0.88, PGCP = 4 × 10–48) and platelet derived growth factor subunit B (PDGFB, GCP = 0.70, PGCP = 2 × 10–17), and lower levels of three blood proteins, including phenylalanyl-tRNA synthetase 2, mitochondrial (FARS2, GCP = 0.69, PGCP = 1 × 10–8), glutathione S-transferase alpha 4 (GSTA4, GCP = 0.56, PGCP = 3 × 10–9) and cysteine rich hydrophobic domain 2 (CHIC2, GCP = 0.37, PGCP = 3 × 10–7). Here, DKK1 is linked to migraine disorder.