Among the identified 36 blood proteins, five proteins have two or more pleiotropic loci with migraine, including four loci for erb-b2 receptor tyrosine kinase 3 (ERBB3), three loci for coagulation factor II thrombin receptor (F2R), and two loci for UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), vascular endothelial growth factor A (VEGFA) and scavenger receptor class F member 2 (SCARF2). This evidence concerns the gene F2R and migraine disorder.