EIF4A1 and hepatocellular carcinoma: eIF4A is the most abundant subunit of eIF4F with RNA-dependent ATPase and RNA helicase activity, playing an important role in the initiation of protein synthesis [39] Studies have demonstrated that eIF4A3 is overexpressed in a variety of tumors, including melanoma, hepatocellular carcinoma, and lymphoma [38,39].