GFAP and Alexander disease: Experimental models suggest that the pathology of some disorders might even be primarily driven by astrocyte defects, for example in Alexander Disease, which is caused by mutations in the GFAP gene (Sosunov et al., 2018), spinocerebellar ataxia 7 (SCA7) (Custer et al., 2006), inflammatory cerebellar ataxias (Lattke et al., 2017), and some forms of epilepsy (Eid et al., 2019; Epi, 2016; Tanaka et al., 1997; Zhou et al., 2019).