IGFBP2 and cancer: Furthermore, the elevated IGFBP2 level had a poor outcome for OS according to cancer type, especially in GBM (HR = 1.36, 95% CI = 1.03–1.79), CRC (HR = 2.52, 95% CI = 1.43–4.44), and other cancers (HR = 2.09, 95% CI = 1.36–3.21) (Figure 4B).