IGFBP2 was found to be highly expressed in many cancers, including glioma,22, 23, 24, 25, 26, 27 lung cancer,28, 29, 30, 31, 32 colorectal cancer,33, 34 ovarian cancer (OC),35, 36 rhabdomyosarcoma,37 gastric cancer,38 breast cancer,39 bladder cancer,40 prostate cancer,41 endometrial cancer,42 penile squamous cell carcinoma,43 and hepatocellular carcinoma.44 Here, IGFBP2 is linked to central nervous system cancer.