IGFBP2 was found to be highly expressed in many cancers, including glioma,22, 23, 24, 25, 26, 27 lung cancer,28, 29, 30, 31, 32 colorectal cancer,33, 34 ovarian cancer (OC),35, 36 rhabdomyosarcoma,37 gastric cancer,38 breast cancer,39 bladder cancer,40 prostate cancer,41 endometrial cancer,42 penile squamous cell carcinoma,43 and hepatocellular carcinoma.44 The gene discussed is IGFBP2; the disease is glioma.