Furthermore, Barlow and colleagues [29] have demonstrated that the IL-33 pathway is more effective than the IL-25 pathway in regulating airway hyperreactivity (AHR) in mouse models of allergic asthma, while Stolarski and colleagues [30] have shown that IL-33 directly stimulated eosinophil differentiation from CD117 + progenitors in IL-5-dependent manner [30]. The gene discussed is IL5; the disease is allergic asthma.