Considering the complicated inflammatory network in patients in cluster 3, developing biologics targeting the factor/s (for example, IL-33, IL-5, IL-13, and TNF-α), which may play a central role in the pathophysiology of disease in these patients, should lead to improvement of both the treatment and prognosis of patients with comorbid asthma and CRS. The gene discussed is TNF; the disease is congenital rubella syndrome.