EGFR and head and neck squamous cell carcinoma: Human papillomavirus negative (HPVneg) head and neck squamous cell carcinoma (HNSCC) is a major subtype of HNSCC, which is associated with poorer clinical outcomes and lower response rate to chemo-radiotherapy as well as treatment targeting EGFR and PD-1 when compared to HPV-positive disease [1–5].