PIK3CA and colorectal carcinoma: First, we compared CRC subgroups based on a combination of these molecular features: I) all-wild-type + pMMR — cases wild-type for all genes (KRAS, PIK3CA, and BRAF) and MMR-proficient (pMMR); II) any-mutation/dMMR — cases with a mutation in any of the genes (KRAS, PIK3CA, and/or BRAF) and/or dMMR.